Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates

摘要

Compounds and compositions are provided, as are methods of using them to treat infections, neoplastic disease, including pancreatic cancer, inflammatory disease, and pain. Such compounds are nucleotides, acyclonucleotides, and ANP phosphonates conjugated with forms and/or moieties of Vitamin B6 for delivery past the cell membrane and into the cell.

主权项

1. A compound having the general structure: wherein R1 is a substituent derived by removal of the hydrogen from the 5′-O-hydroxyl of a nucleoside or removal of an equivalent hydrogen from an acyclonucleoside; X and Y are independently O, S, or NH; and R2 and R3 are independently selected from the group consisting of H, phenyl, alkyl, aryl, heteroaryl, and a vitamin B6 moiety having one of the structures wherein at least one of R2 and R3 is a vitamin B6 moiety.