| 摘要 |
Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula (I), wherein the position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections. |
| 申请人 |
GILEAD SCIENCES, INC. |
发明人 |
AXT, STEVEN, DONALD;BADALOV, PAVEL, ROBERTOVICH;BRAK, KATRIEN;CAMPAGNA, SILVIO;CHTCHEMELININE, ANDREI;CHUN, BYOUNG, KWON;CLARKE, MICHAEL, O'NEIL HANRAHAN;DOERFFLER, EDWARD;FRICK, MORIN, MAE;GAO, DETIAN;HEUMANN, LARS, V.;HOANG, BRITTANIE;HUI, HON, CHUNG;JORDAN, ROBERT;LEW, WILLARD;MACKMAN, RICHARD, L.;MILBURN, ROBERT, RONALD;NEVILLE, SEAN, TIMOTHY;PARRISH, JAY P.;RAY, ADRIAN, S.;ROSS, BRUCE;RUEDEN, ERIK;SCOTT, ROBERT WILLIAMS;SIEGEL, DUSTIN;STEVENS, ANDREW C.;TADEUS, CLARISSA;VIEIRA, TIAGO;WALTMAN, ANDREW W.;WANG, XIANGHONG;WHITCOMB, MARK CHARLES;WOLFE, LYDIA;YU, CHIA-YUN |
