摘要 |
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed. |
申请人 |
E. R. Squibb & Sons, L.L.C. |
发明人 |
Terrett, Jonathan Alexander;Lu, Li-sheng;Huang, Haichun;Yao, Dapeng;Pan, Chin;Leblanc, Heidi;Sproul, Timothy;Yamanaka, Mark |