SYSTEMS AND METHODS OF SCREENING WITH A MOLECULE RECORDER
摘要
The present invention is directed to compositions and methods related to nucleotide enzymes and their use in screening assays, the enzyme comprising two substrate binding domains, the target or effector binding domain allosterically responding to initiate ligation activity by a nucleotide enzyme moiety and releasing the ligated oligonucleotide as a reporter for the detected moiety.
申请公布号
WO2016069539(A1)
申请公布日期
2016.05.06
申请号
WO2015US57479
申请日期
2015.10.27
申请人
HELIX NANOTECHNOLOGIES, INC.
发明人
NAMIH, CARINA;WENDELSTADT, KATHARINA;SIWO, GEOFFREY;RAJANIEMI, HANNU;LOOS, REMCO;COTOBAL, CRISTINA;SMALLIE, TIM