发明名称 |
IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC |
摘要 |
The present invention relates to a compound of formula (I): wherein R1is R3-IPU and R2 is the acyloxy residue of diclofenac, and specified by the following structures: (II), (III) wherein OH-R3-IPU is selected from (IV) and R4 and R5 may be the same or different selected from H and CH3 and salts, solvates and hydrates thereof. The compounds are used for the treatment of pain such as postoperative pain following arthroscopic surgery. |
申请公布号 |
WO2016066612(A1) |
申请公布日期 |
2016.05.06 |
申请号 |
WO2015EP74809 |
申请日期 |
2015.10.27 |
申请人 |
LARSEN, CLAUS SELCH |
发明人 |
LARSEN, CLAUS SELCH;LARSEN, SUSAN WENG;THING, METTE AGERGAARD;KRISTENSEN, JESPER LANGGAARD;JENSEN, HENRIK;ØSTERGAARD, JESPER |
分类号 |
C07D233/61;A61K31/4164;A61P19/00;A61P29/00 |
主分类号 |
C07D233/61 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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