COMBINATION THERAPY FOR TREATING VIRAL RESERVOIRS

摘要

Compositions and methods are provided for reducing viral reservoirs. Stimulating viral reservoirs under conditions that reduce or clear active virus out of the body provides a two-step approach for flushing and eradicating viral reservoirs. Administration of a shock agent such as an anti-viral DNA vaccine reactivates viral reservoirs and a kill agent, such as an anti-viral vaccine or anti-viral antibody, recognizes and kills reactivated cells in the presence of systemic antiretroviral drugs to reduce or prevent infection of uninfected cells. A multiple administration regime provides repeated stimulation and flushing of viral reservoirs for effective treatment.