发明名称 |
POLYHETEROARYL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY |
摘要 |
The present invention is a compound having the following formula: or a pharmaceutically acceptable salt thereof, wherein e.g. L and Y are each independently an optionally substituted 6-membered nitrogen-containing heteroaryl; M is an optionally substituted 5- to 10-membered heteroaryl; W is a zinc-binding group; each R2 is independently hydrogen or C1-C6 alkyl; and R3 is an aryl or heteroaryl. The compounds are useful as histone deacetylase (HDAC) inhibitors. |
申请公布号 |
WO2016067038(A1) |
申请公布日期 |
2016.05.06 |
申请号 |
WO2015GB53256 |
申请日期 |
2015.10.29 |
申请人 |
KARUS THERAPEUTICS LTD |
发明人 |
SHUTTLEWORTH, STEPHEN JOSEPH;CECIL, ALEXANDER RICHARD LIAM;MACCORMICK, SOMHAIRLE;NODES, WILLIAM JOHN;TOMASSI, CYRILLE DAVY;SILVA, FRANCK ALEXANDRE |
分类号 |
C07D401/14;A61K31/497;A61K31/506;A61P29/00;A61P35/00;C07D405/14;C07D413/14;C07D471/04 |
主分类号 |
C07D401/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|