| 发明名称 |
COAGULATION FACTOR VII POLYPEPTIDES |
| 摘要 |
The present invention relates to modified coagulation Factor VII polypeptides exhibiting increased resistance to antithrombin inactivation and enhanced proteolytic activity. The present invention also relates to polynucleotide constructs encoding such polypeptides, vectors and host cells comprising and expressing such polynucleotides, pharmaceutical compositions, uses and methods of treatment. |
| 申请公布号 |
US2016120992(A1) |
申请公布日期 |
2016.05.05 |
| 申请号 |
US201514936224 |
申请日期 |
2015.11.09 |
| 申请人 |
NOVO NORDISK HEALTHCARE AG |
发明人 |
Oestergaard Henrik;Gandhi Prafull S.;Olsen Ole Hvilsted;Behrens Carsten;DeAngelis Paul L.;Haller Friedrich Michael |
| 分类号 |
A61K47/48;A61K38/36 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A conjugate comprising a structure conjugated to an N-glycan on a Factor VII (FVII) variant, wherein said FVII variant comprises L288Y and T293K substitutions relative to the amino acid sequence of SEQ ID NO: 1, wherein the structure comprises and wherein n is an integer from 95-115. |
| 地址 |
Zurich CH |
