| 发明名称 |
COMPOSITIONS AND METHODS FOR MODULATION OF IMMUNE FUNCTION |
| 摘要 |
Compositions and methods for modulating immune cell function and Nedd-4 family member signaling are disclosed. |
| 申请公布号 |
US2016122404(A1) |
申请公布日期 |
2016.05.05 |
| 申请号 |
US201414889728 |
申请日期 |
2014.05.07 |
| 申请人 |
THE CHILDREN'S HOSPITAL OF PHILADELPHIA |
发明人 |
Oliver Paula M.;Riling Chris |
| 分类号 |
C07K14/47;G01N33/573;A61K9/127;A61K45/06;A61K38/17 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition which relieves auto-inhibition of Itch or Nedd4-family members comprising a HECT domain, comprising one or more peptides or variants thereof, selected from the group consisting of:1)PEQTAGDAPPPYSSITAESAAYFDY;2)GDAPPPYSSITAESAAYFDYKDESGFPKPPSYNVA;and3)GDAPPPYSSITAESAAYFDYKDESGFPKPPSYNVATTLPSYDEAE in a pharmaceutically acceptable carrier, said peptide optionally being contained within a lipsome. |
| 地址 |
Philadelphia PA US |
