Pegylated Aß Fab

摘要

PEGYLATED AQ FAB Abstract A pharmaceutical composition suitable for subcutaneous administration is described. The composition comprises an antibody fragment that specifically binds human AP peptide between amino acid positions 13-28, wherein the antibody fragment comprises a light chain variable region of SEQ ID NO: 1 and a heavy chain variable region of SEQ ID NO: 2, and wherein a polyethylene glycol molecule is covalently attached to a CDR of the heavy chain variable region of the antibody fragment. Methods of treatment employing such compositions are also described, as is the use of such compositions for the preparation of a medicament for such treatments.