| 发明名称 |
PREDICTING IMMUNOGENICITY OF T CELL EPITOPES |
| 摘要 |
The present invention relates to methods for predicting T cell epitopes. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic or not. The methods of the invention are useful, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines. |
| 申请公布号 |
US2016125129(A1) |
申请公布日期 |
2016.05.05 |
| 申请号 |
US201414787110 |
申请日期 |
2014.05.07 |
| 申请人 |
BIONTECH AG ;TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄ- TSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAIN |
发明人 |
Sahin Ugur;Tadmor Arbel David;Castle John Christopher;Boegel Sebastian;Löwer Martin |
| 分类号 |
G06F19/18;A61K39/00;C12Q1/68 |
主分类号 |
G06F19/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for predicting immunogenic amino acid modifications, the method comprising the steps:
a) ascertaining a score for binding of a modified peptide to one or more MHC molecules, and b) ascertaining a score for binding of the non-modified peptide to one or more MI-IC molecules, and/or c) ascertaining a score for binding of the modified peptide when present in a MHC-peptide complex to one or more T cell receptors. |
| 地址 |
Mainz DE |
