发明名称 |
New telescoping synthesis of 2-methoxymethyl-p-phenylenediamine |
摘要 |
A telescoping process for the preparation of 2-methoxymethyl-p-phenylenediamine, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely 2-methoxymethylaniline. |
申请公布号 |
US2016122284(A1) |
申请公布日期 |
2016.05.05 |
申请号 |
US201514926135 |
申请日期 |
2015.10.29 |
申请人 |
The Procter & Gamble Company |
发明人 |
ABEL Heike Gertrud;OSAN Armin;SPECKBACHER Markus;WEBER Ingo Reinhold;GARRETT Garry Steven |
分类号 |
C07C209/24 |
主分类号 |
C07C209/24 |
代理机构 |
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代理人 |
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主权项 |
1. A telescoping process for the preparation of 2-methoxymethyl-p-phenylenediamine (I), a cosmetically acceptable salt thereof, or mixture thereof comprising the steps of:
a) synthesizing the intermediate 2-(methoxymethyl)-4-{3-[2-(methoxymethyl)phenyl]triaz-1-en-1-yl}aniline (IV) via diazotation using 2-methoxymethylaniline (II) to obtain the intermediate of formula (III) followed by diazo coupling between the intermediate of formula (III) and 2-methoxymethylaniline (II): b) synthesizing the intermediate 2-(methoxymethyl)-4-{(E)-[2-(methoxymethyl)phenyl]diazenyl}aniline (V) via rearrangement of the intermediate 2-(methoxymethyl)-4-{3-[2-(methoxymethyl)phenyl]triaz-1-en-1-yl}aniline (IV) obtained in step a): c) synthesizing 2-methoxymethyl-p-phenylenediamine (I) and 2-methoxymethylaniline (II) via hydrogenation of the compound of formula (V): |
地址 |
Cincinnati OH US |