BILE SALT HYDROLASE BSH1 FOR REGULATING WEIGHT GAIN, SERUM CHOLESTEROL LEVELS, AND LIVER TRIGLYCERIDES IN A MAMMAL; BACTERIA STRAINS EXPRESSING BSH1 VARIANTS

摘要

A non-therapeutic method of reducing weight gain, serum cholesterol levels, or liver triglyceride levels, in a non-obese mammal, comprises the step of administering to the gut of a mammal an effective amount of a bacteria expressing a BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof; a BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof for use as a medicament; isolated bacterial strains expressing functional variants of BSH1.

主权项

1. A non-therapeutic method of reducing weight gain, serum cholesterol levels, or liver triglyceride levels, in a non-obese mammal, or a method of treating or preventing obesity, hypercholesterolemia or a disease or condition associated with dysregulated circadian rhythm, comprising the step of administering to the gut of a mammal an active agent comprising a bacteria that expresses BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof having at least 90% sequence identity with SEQUENCE ID NO: 1.