| 发明名称 |
CARTILAGE-BINDING FUSION PROTEINS |
| 摘要 |
Provided herein are fusion proteins comprising a first domain that specifically binds to the extracellular domain of a growth factor receptor, and a second domain that specifically binds to a cartilage matrix component, and pharmaceutical composition comprising these fusion proteins. Methods of treating musculoskeletal diseases using the fusion proteins and pharmaceutical composition disclosed herein are also provided. |
| 申请公布号 |
US2016122411(A1) |
申请公布日期 |
2016.05.05 |
| 申请号 |
US201414770749 |
申请日期 |
2014.03.28 |
| 申请人 |
MERRIMACK PHARMACEUTICALS, INC. |
发明人 |
Florine Emily;Kirpotin Dmitri B.;Kopesky Paul;Lugovskoy Alexey;Rennard Rachel;Schoeberl Birait |
| 分类号 |
C07K14/65;A61K38/30;A61K9/00;A61K31/573;A61K9/50;A61K9/127;C07K14/47;A61K38/17 |
主分类号 |
C07K14/65 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion protein comprising a first binding domain and a second binding domain, wherein, when present in the fusion protein, the first domain binds specifically to an extracellular domain of the growth factor receptor, and the second domain binds specifically to the cartilage matrix component. |
| 地址 |
Cambridge MA US |
