FC RECEPTOR (FcRn) BINDING PEPTIDES AND USES THEREOF

摘要

The invention provided herein includes isolated polypeptides that specifically block the interaction between neonatal Fc receptor (FcRn) and albumin. Blocking the interaction treats diseases and conditions caused by increased amounts of albumin or modified albumin that possesses pathogenic properties wherein it is deemed desirable to decrease albumin levels. Accordingly, also provided are methods of using these isolated polypeptides to treat various diseases and conditions caused by increased amounts of albumin or modified albumin that possesses pathogenic properties. The invention provided herein also includes isolated polypeptides capable of binding to a non-IgG and non-albumin competitive site on an FcRn alpha 3 domain. These can be useful for tracking FcRn without inhibiting IgG or albumin binding or function. Accordingly, the invention also includes methods and systems to track FcRn without inhibiting IgG or albumin binding or function.

主权项

1. An isolated polypeptide that specifically blocks the interaction between neonatal Fc receptor (FCRN) and albumin comprising at least one peptide subunit consisting of an amino acid sequence X1-Y-X2-C-X3-X4-W-X5-X6-X7-W-C-X8-X9-V-X10-X11 (SEQ ID NO:7), wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, and X11 is each independently selected from any amino acid, or is deleted.