USES OF IL-12 IN HEMATOPOIETIC IMMUNOTHERAPY (HIT)

摘要

Aspects and embodiments of the instant disclosure provide therapeutic methods and compositions comprising interleukin 12 (IL-12) as a hematopoietic immunotherapy (HIT) useful for treating or preventing a cancer patient from chemotherapy-induced cytopenias necessitating a dose reduction and/or dose delay. following exposure of the patient to chemotherapeutic agents, the method comprising: administering a dose of therapeutically effective amount of a pharmaceutical composition comprising substantially isolated IL-12 to the subject, whereby cytopenias are reduced and leading to increases responses to the chemotherapy agent(s).diminished.

主权项

1. A method for increasing survival in a subject with cancer, wherein the method comprises:
administering a therapeutically effective amount of a composition comprising IL-12 to the subject receiving a predetermined chemotherapy and/or chemoradiotherapy regimen, wherein the administration of IL-12 reduces the likelihood and/or severity of occurrence of at least two cytopenias inducible by chemotherapy and/or chemoradiotherapy; whereby the need for subsequent adjustment of the chemotherapy and/or chemoradiotherapy dose regimen resulting from the induction of cytopenia is mitigated.