发明名称 |
Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation |
摘要 |
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that exhibits alpha-adrenergic activity and one or more additional pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for peripheral vasoconstriction and inhibition of pain and/or inflammation while avoiding undesirable side effects associated with systemic application of larger doses of the agents. |
申请公布号 |
US2016120846(A1) |
申请公布日期 |
2016.05.05 |
申请号 |
US201514937002 |
申请日期 |
2015.11.10 |
申请人 |
Omeros Corporation |
发明人 |
Demopulos Gregory A.;Palmer Pamela Pierce;Herz Jeffrey M. |
分类号 |
A61K31/4174;A61K31/135;A61K31/415;A61K38/08;A61K31/4406;A61K31/506;A61K31/192;A61K9/127 |
主分类号 |
A61K31/4174 |
代理机构 |
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代理人 |
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主权项 |
1. A composition for use in the inhibition of pain and inflammation at a joint of an extremity or at a wound at an extremity, the composition comprising:
an alpha-1 selective adrenergic receptor agonist; and at least a first pain/inflammation inhibitory agent comprising a cyclooxygenase inhibitor. |
地址 |
Seattle WA US |