DISSOLVABLE SLEEVE CONFIGURATIONS TO AID GRAFT DEPLOYMENT

摘要

A prosthesis including a self-expanding stent, a graft body, and one or more sleeves is disclosed, in addition to methods of treatment using the prosthesis. The proximal and distal ends of the prosthesis may include one or more sleeves and one or more barbs. The sleeves may be removable or dissolvable, for example, upon exposure to an activating agent. The prosthesis may be used to treat lacerated vessels and transected vessels.

主权项

1. A method of open surgical repair of a lacerated or transected body vessel to obtain fluid stability while maintaining fluid flow through the body vessel, comprising:
inserting a distal end of a prosthesis into a first vessel portion of the body vessel, wherein the prosthesis comprises a self-expanding stent and a graft body, the distal end of the prosthesis being retained in a radially compressed configuration with a distal end sleeve comprising a section having a thinner wall thickness and a section having a thicker wall thickness, wherein the section having the thicker wall thickness is located proximally adjacent the section having the thinner wall thickness; applying an activating agent to the distal end sleeve; dissolving the distal end sleeve thereby allowing a distal end of the self-expanding stent to expand and engage the first vessel portion, the section having the thinner wall thickness dissolving before the section having the thicker wall thickness thereby allowing a distal-most end to expand and contact the vessel before the proximally adjacent portion; inserting a proximal end of the prosthesis into a second vessel portion of the body vessel, the proximal end of the prosthesis being retained in a radially compressed configuration with a proximal end sleeve comprising a section having a thinner wall thickness and a section having a thicker wall thickness, wherein the section having the thicker wall thickness is located distally adjacent the section having the thinner wall thickness; applying the activating agent to the proximal end sleeve; and dissolving the proximal end sleeve thereby allowing a proximal end of the self-expanding stent to expand and engage the second vessel portion, the section having the thinner wall thickness dissolving before the section having the thicker wall thickness thereby allowing a proximal-most end to expand and contact the vessel before the distally adjacent portion; the prosthesis comprising a longitudinal length sufficient to bridge and seal the laceration or bridge and interconnect the gap between the transection.