METHOD FOR PREDICTING THE RESPONSE TO TREATMENT WITH RADIOTHERAPY COMBINED WITH CHEMOTHERAPY BASED ON CISPLATIN

摘要

The invention relates to a method to predict the response to treatment with radiotherapy combined with cisplatin-based chemotherapy in patients with cancer, preferably non-microcytic lung cancer, wherein said method is based on the detection of the presence of methylation in the IGFBP-3 gene. The present invention also relates to an in vitro method to design a customised treatment for an individual with said disease. The method of the invention may be quantitative or semi-quantitative. The present invention also relates to a probe designed for the quantitative detection of the methylation of the IGFBP-3 gene, to a kit that comprises it and to the use of the kit to predict the response of a subject to the aforementioned treatment.

主权项

1. Method to obtain useful data to predict the response of a subject with cancer to treatment with radiotherapy combined with cisplatin-based chemotherapy, which comprises detecting and/or quantifying the promoter methylation of the IGFBP-3 gene in a biological sample from said subject.