Method for the production of a glycosylated immunoglobulin
摘要
METHOD FOR THE PRODUCTION OF A GLYCOSYLATED IMMUNOGLOBULIN Herein is reported a method for the production of an immunoglobulin comprising the following steps: a) providing a eukaryotic cell comprising a nucleic acid encoding the immunoglobulin, b) cultivating the eukaryotic cell in a cultivation medium wherein the amount of glucose available in the cultivation medium per time unit is kept constant and limited to less than 80 % of the amount that could maximally be utilized by the cells in the cultivation medium per time unit, and c) recovering the immunoglobulin from the culture.
申请公布号
AU2015203309(B2)
申请公布日期
2016.05.05
申请号
AU20150203309
申请日期
2015.06.17
申请人
CHUGAI SEIYAKU KABUSHIKI KAISHA;F. HOFFMANN-LA ROCHE AG