GENETIC TEST

摘要

The present invention relates to a method of determining the susceptibility of a dog to, or the likelihood that a dog is protected from, hip dysplasia. The present invention uses mutations linked to canine hip dysplasia to generate a model predicting disease.

主权项

1. A method comprising determining the susceptibility of a first dog to hip dysplasia based upon the presence or absence of one or more mutations in one or more genes selected from the group consisting of:GeneLocationLaminin alpha 2Chromosome 1: 70,790,697-71,150,490subunit FragmentLSM4 homolog, U6 smallChromosome 20: 47,714,464-47,721,805nuclear RNA associatedCollagen, type VI, alpha 3Chromosome 25: 50,995,186-51,063,665CDP-diacylglycerolChromosome 32: 11,331,461-11,375,767synthase (phosphatidatecytidylyltransferase) 1inositol polyphosphate-Chromosome 25: 47,629,437-47,731,0965-phosphataseSH3-domain binding protein 4Chromosome 25: 49,142,306-49,155,351histone deacetylase 4Chromosome 25: 52,342,017-52,443,682Leucine rich repeat protein 1Chromosome 8: 29,236,409-29,246,995v-ski sarcoma viralChromosome 5: 60,146,103-60,213,750oncogene homologprostaglandin D2Chromosome 8: 31,485,692-31,494,066 In the genome of the first dog.