CONTINUOUS PRODUCTION METHOD FOR 5-AMINOLEVULINIC ACID BY USING PHOTOSYNTHETIC MEMBRANE VESICLE

摘要

A method of continuously producing 5-aminolevulinic acid employs the photosynthetic bacteria-derived photosynthetic membrane vesicle, succinyl-CoA synthetase, and 5-aminolevulinic acid synthase. The enzymatic synthesis of 5-aminolevulinic acid directly from succinic acid and glycine may be simple, but the synthesis is not inexpensive due to the supply of ATP and CoA, which are relatively expensive reactants. The photosynthetic membrane vesicle is used together with succinyl-CoA synthetase and 5-aminolevulinic acid synthase, thereby enabling the re-use of adenosine diphosphate or CoA in reaction. Accordingly, relatively expensive 5-aminolevulinic acid can be efficiently produced at low manufacturing costs from succinic acid and glycine.

主权项

1. A method of producing 5-aminolevulinic acid, the method comprising light irradiation to the photosynthetic membrane vesicle to produce adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate with the use of a photosynthetic membrane vesicle, a succinyl-CoA synthetase, and a 5-aminolevulinic acid synthase (ALA synthase).