Molecules Associated with Fatty Acid Biosynthetic Pathways and Uses Thereof

摘要

The present disclosure relates in part to recombinant microorganisms that include non-native genes encoding PUFA-PKS polypeptides, and to methods of making and using such microorganisms for producing at least one PUFA. In particular, the disclosure further relates to methods and related materials useful for the production of at least one PUFA by heterologous expression of the nucleic acid sequences disclosed herein encoding PUFA-PKS polypeptides.

主权项

1. A recombinant eukaryotic microorganism comprising at least one non-native nucleic acid sequence encoding a prokaryotic polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) system, wherein the eukaryotic microorganism produces at least 50% more EPA than a control eukaryotic host cell.