LIPID-BASED PLATINUM-N-HETEROCYCLIC CARBENE COMPOUNDS AND NANOPARTICLES

摘要

The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to carbene compounds, particularly platinum containing carbenes and corresponding nanoparticles thereof. The disclosure further relates to synthesis of said platinum containing carbenes, nanoparticles and compositions comprising said platinum containing carbenes/nanoparticles. The disclosure also relates to methods of managing cancer by employing aforesaid platinum based compounds, nanoparticles and compositions.

主权项

1. A compound of:
(i) Formula (VI): whereinX1, X2, X3 and X4 are selected independently from the group consisting of O, P, S, Se, Cl, N, C, O-A, O—B, DACH, halides and chelated or non-chelated dicarboxylato linkage group, and any combinations thereof;wherein A and B are selected independently from the group consisting of C, P, S, N, and any combinations thereof; andwherein X4 is optional; or (ii) Formula (I): wherein:R1, R2, R3, R4 are independently halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, chelated or non-chelated dicarboxylato linkage, -linker-lipid, O, P, S, Se, Cl, N, C, O-A, O—B, DACH or any combination thereof; andA and B are selected independently from the group consisting of C, P, S, N, and any combination thereof,provided that at least one of R1, R2, R3, and R4 is a carbene compound; or (ii) Formula (II): wherein:R1, R2, R3, R4, R5 and R6 are independently halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, chelated or non-chelated dicarboxylato linkage, -linker-lipid, O, P, S, Se, Cl, N, C, O-A, O—B, DACH or any combination thereof; andA and B are selected independently from the group consisting of C, P, S, N, and any combination thereof,provided that at least one of R1, R2, R3, and R4 is a carbene compound.