发明名称 |
Pharmaceutical compositions comprising 8-substituted dibenzylbutyrolactone lignans |
摘要 |
Therapeutic compositions comprising at least one 8-substituted-dibenzylbutyrolactone lignan, preferably a lignan is selected from the group of nortrachelogenin, diasteromeric forms of nortrachelogenin, isomeric forms of nortrachelogenin and combinations thereof as well as 8-methylmatairesinol and 8-methyldimethylmatairesinol, for use in a method of treating cancer or a similar condition wherein the growth factor signaling pathway of a mammal is deregulated. The invention also provides therapeutic pharmaceutical combinations comprising a hydroxy-dibenzylbutyrolactone lignan and at least one TRAIL receptor agonist. The hydroxy-dibenzylbutyrolactone lignans and a TRAIL receptor agonist can be used as a combined preparation for administration to a patient simultaneously, separately or spaced out over a period of time in treating cancer. |
申请公布号 |
US2016120937(A1) |
申请公布日期 |
2016.05.05 |
申请号 |
US201514922228 |
申请日期 |
2015.10.26 |
申请人 |
Peuhu Emilia;Eriksson John;Holmbom Thomas;Eklund Patrik;Sjoholm Rainer |
发明人 |
Peuhu Emilia;Eriksson John;Holmbom Thomas;Eklund Patrik;Sjoholm Rainer |
分类号 |
A61K38/16 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
1. A therapeutic composition comprising a 8-hydroxy- or 8-substituted-dibenzylbutyrolactone lignin. |
地址 |
Abo FI |