| 摘要 |
The present invention provides a new non-invasive detecting method for chromosomal abnormality of a fetus, in which a next generation sequencing (NGS) technology is applied to the method. The present invention relates to the non-invasive detecting method for the chromosomal abnormality of the fetus, including the steps of: classifying, in a distribution map of a reference base sequence read group reflecting a Euclidean distance between reference base sequence read groups of mothers who had fetal diagnosis, the reference base sequence read groups as a plurality of reference base sequence read communities; selecting a first reference base sequence read group positioned in a central part of a first reference base sequence read community and a second reference base sequence read group positioned in a central part of a second reference base sequence read community from the multiple reference base sequence read community; comparing a first Euclidean distance between a test base sequence read group of a mother having the fetal diagnosis and the first reference base sequence read group with a second Euclidean distance between the test base sequence read group and the second reference base sequence read group; and determining which community, from the first reference base sequence read community or the second reference base sequence read community, the test base sequence read group belongs to. |
