发明名称 |
GOLD IMPLANTATION/DEPOSITION ON BIOLOGICAL SAMPLES FOR LASER DESORPTION THREE DIMENSIONAL DEPTH PROFILING OF TISSUES |
摘要 |
The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer. |
申请公布号 |
EP1648595(B1) |
申请公布日期 |
2016.05.04 |
申请号 |
EP20040754363 |
申请日期 |
2004.06.04 |
申请人 |
IONWERKS |
发明人 |
SCHULTZ, J., ALBERT;UGAROV, MICHAEL;EGAN, THOMAS, F.;TEMPEZ, AGNES;LE BAYEC, YVON;NEGRA, SERGE, DELLA |
分类号 |
H01J49/04;B01D59/44;H01J;H01J49/00;H01J49/16;H01J49/40 |
主分类号 |
H01J49/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|