发明名称 |
Method for the Detection of Antigen Presentation |
摘要 |
The present invention pertains to a method for detecting antigen presentation via antigen presenting molecules such as major histocompatibility complex (MHC) class I or II. The invention deploys a first binding agent specific for the antigen epitope and a second binding agent specific for the antigen presenting molecule. The binding agents of the invention are coupled to proximity probes which upon antigen presentation elicit a detectable signal. The method of the invention allows detecting antigen presentation via MHC in-vitro and in a tissue sample in-situ. Thus the method of the present invention finds application as a new diagnostic tool, for example in the diagnosis of various diseases such as infectious diseases, immunological disorders, in particular autoimmune diseases, and proliferative disorders such as cancer. |
申请公布号 |
EP3015862(A1) |
申请公布日期 |
2016.05.04 |
申请号 |
EP20140190538 |
申请日期 |
2014.10.27 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS;RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG |
发明人 |
PLATTEN, MICHAEL;SCHUMACHER, THERESA;BUNSE, LUKAS;WICK, WOLFGANG;SAHM, FELIX |
分类号 |
G01N33/542 |
主分类号 |
G01N33/542 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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