| 发明名称 |
METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES |
| 摘要 |
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone. |
| 申请公布号 |
EP3013852(A1) |
申请公布日期 |
2016.05.04 |
| 申请号 |
EP20140817079 |
申请日期 |
2014.06.26 |
| 申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
MESSER, WILLIAM;BARIC, RALPH;DESILVA, ARAVINDA;YOUNT, BOYD |
| 分类号 |
C07K14/005;A61K38/16;A61P31/12;C07K14/18;C12N15/62 |
主分类号 |
C07K14/005 |
| 代理机构 |
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