发明名称 |
IMPROVED PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-FLUORO[1,1'-BIPHENYL]-4-YL)-CYCLOPROPANECARBOXYLIC ACID |
摘要 |
The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain. |
申请公布号 |
EP3013786(A1) |
申请公布日期 |
2016.05.04 |
申请号 |
EP20140736326 |
申请日期 |
2014.06.20 |
申请人 |
CHIESI FARMACEUTICI S.P.A. |
发明人 |
VERZINI, MASSIMO;COTARCA, LIVIUS;GUIDI, ALBERTO;MELLONI, ALFONSO;MARAGNI, PAOLO |
分类号 |
C07C67/30;C07C253/30 |
主分类号 |
C07C67/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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