| 摘要 |
A conjugate comprising a protein, peptide and/or polymer attached to a maytansine containing payload via a linker, characterised in that the maytansine-containing payload consists of at least two maytansine moieties linked to each other through a non-degradable bridging group, with the proviso that when the conjugate comprises a protein or peptide, the linker attaching the payload to the protein or peptide is degradable. Also disclosed is a conjugating reagent that comprises said maytansine containing payload, a maytansine-containing compound as defined therein and a process for the preparation of said conjugate. |
