发明名称 |
MORPHOLINO OLIGONUCLEOTIDE MANUFACTURING METHOD |
摘要 |
Using a morpholino nucleotide wherein 5'-hydroxy group or a hydroxy group present on the substituent of the 5'-hydroxy group is protected by a protecting group having an alkyl group having not less than 10 and not more than 300 carbon atoms and/or an alkenyl group having not less than 10 and not more than 300 carbon atoms as a starting material, a method capable of efficiently producing the morpholino oligonucleotide in a high yield by a liquid phase synthesis can be provided. |
申请公布号 |
EP3015467(A1) |
申请公布日期 |
2016.05.04 |
申请号 |
EP20140800406 |
申请日期 |
2014.05.23 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
TORII, TAKAYOSHI;TAKAHASHI, DAISUKE;KATAYAMA, SATOSHI |
分类号 |
C07D413/04;A61K31/5377;A61K48/00;C07D487/04;C07D519/00 |
主分类号 |
C07D413/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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