Apparatus and methods to operate a microreactor

摘要

The present invention provides apparatus and methods to operate microreactor devices through the controlled delivery of pressurized fluids. A heated reservoir, a heated manifold, and a heater for the microreactor device provides for the delivery of a pressurized gas while minimizing evaporation and condensation; and a fluid interface and pressure interlock provides for the delivery of aseptic fluids while minimizing contamination and fluid loss.

主权项

1. An apparatus to operate a microreactor device, the microreactor device having a first side and a second side, said first side having a first opening and a second opening, the apparatus comprising:
a first heater; a base plate, in thermal communication with the first heater, comprising: a thermally conductive material; and a control conduit with a first opening on a first substantially planar surface of the base plate and a second opening on a second substantially planar surface of the base plate, said second opening in fluid communication with the first opening of the microreactor device, wherein at least a portion of the length of the control conduit runs laterally across the base plate; a first pressure source; a reservoir, comprising a thermally conductive material, in thermal communication with the base plate and in fluid communication with the first pressure source; a vent conduit; a 3-way solenoid switch comprising a first port in fluid communication with the first opening of the control conduit; a second port in fluid communication with the reservoir; and a third port in fluid communication with the vent conduit, wherein the 3-way solenoid switch in an on-state fluidically connects the first port and the second port and fluidically isolates the third port, and the 3-way solenoid switch in an off-state fluidically connects the first port and the third port and fluidically isolates the second port; and a second heater in thermal communication with the second side of the microreactor device.