| 摘要 |
In one aspect, the invention relates to novel, broad-spectrum anti-viral, pyrimidinone compounds, methods of use, compositions and kits useful in treating and/or preventing influenza. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| 主权项 |
1. A compound of the formula: wherein R1 is an optionally substituted heteroaryl; wherein R3 is optionally substituted and selected from cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —CONR4R5, and —COR6; wherein R4 and R5 are each optionally substituted and independently selected from hydrogen, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein at least one of R4 or R5 is not hydrogen, and provided that when R1 is a heteroaryl group having 6 or more ring members, then neither R3 nor R4 is hydrogen; or wherein —NR4R5 together form an optionally substituted ring selected from piperidinyl, morpholinyl, and piperazinyl; and wherein R6 is optionally substituted and selected from alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, phenyl, pyridazinyl, pyrimidyl, pyrazyl, triazinyl, pyrrolyl, pyrazolyl, imidazolyl, (1,2,3,)- and (1,2,4)-triazolyl, pyrazinyl, pyrimidinyl, tetrazolyl, thienyl, isoxazolyl, thiazolyl, and oxazolyl, or a pharmaceutically acceptable salt thereof. |
