发明名称 |
RESOLUTION AND PURIFICATION OF TRANS-(-)-DELTA-9-TETRAHYDROCANNABINOL AND TRANS-(+)-DELTA-9-TETRAHYDROCANNABINOL BY CHIRAL CHROMATOGRAPHY |
摘要 |
Methods for making trans-(-)-.DELTA.9-tetrahydrocannabinoI and trans-(+)-.DELTA.9-tetrahydrocannabinol are disclosed herein. In one embodiment, a trans-(-)-.DELTA.9-tetrahydrocannabinoI composition is prepared by allowing a composition comprising (~)-.DELTA.9-tetrahydrocannabinol to separate on a chiral stationary phase to provide a trans-(-)-.DELTA.9-tetrahydrocannabinoI composition comprising at least about 99% by weight of trans-(-)-.DELTA.9-tetrahydrocannabinol based on the total amount of trans-(-)-.DELTA.9-tetrahydrocannabinol and trans-(+)-.DELTA.9-tetrahydrocannabinol. The invention also relates to methods for treating or preventing a condition such as pain comprising administering to a patient in need thereof an effective amount of a trans-(-)-.DELTA.9-tetrahydrocannabinoI having a purity of at least about 98% based on the total weight of cannabinoids. |
申请公布号 |
CA2587957(C) |
申请公布日期 |
2016.05.03 |
申请号 |
CA20052587957 |
申请日期 |
2005.11.18 |
申请人 |
EURO-CELTIQUE S.A. |
发明人 |
GUTMAN, ARIE L.;NISNEVICH, GENNADY A.;RUKHMAN, IGOR;TISHIN, BORIS;ETINGER, MARINA;FEDOTEV, IRINA;PERTSIKOV, BORIS;KHANOLKAR, RAM |
分类号 |
A61K31/352;A61P1/08;A61P3/00;A61P29/00;C07D311/80 |
主分类号 |
A61K31/352 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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