Selective drug delivery in a lumen

摘要

Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue.

主权项

1. A medical device, comprising:
a catheter shaft having a distal region; an expandable member coupled to the distal region; a coating disposed along the expandable member, the coating including a releasable drug; a plurality of electrodes coupled to the expandable member; wherein the plurality of electrodes includes one or more pairs of bipolar electrodes; and wherein the electrodes are configured to induce a phase change in the coating and release the releasable drug from the coating.