| 发明名称 |
siRNA useful in the treatment of flavivirus infection |
| 摘要 |
Pharmaceutical compositions that comprise an siRNA molecule used in the treatment of diseases caused by flavivirus infection and methods of their use are disclosed. The pharmaceutical compositions treat diseases caused by yellow fever virus, West Nile virus, and dengue virus and include a single pharmaceutical composition active against all four dengue virus serotypes. |
| 申请公布号 |
US9328347(B2) |
申请公布日期 |
2016.05.03 |
| 申请号 |
US201214233494 |
申请日期 |
2012.07.17 |
| 申请人 |
OREGON HEALTH & SCIENCE UNIVERSITY |
发明人 |
Stein David A.;Frueh Klaus |
| 分类号 |
C12N15/11;C12N15/113 |
主分类号 |
C12N15/11 |
| 代理机构 |
|
代理人 |
Jackson Jeffrey M. |
| 主权项 |
1. A pharmaceutical composition comprising:
a therapeutically effective amount of an siRNA comprising a first nucleic acid, the first nucleic acid comprising a polyribonucleic acid sequence selected from the group consisting of SEQ ID NO: 12 and SEQ ID NO: 19. |
| 地址 |
Portland OR US |
