发明名称 |
ensaio de alto rendimento para a avaliação da atividade de dipeptidil peptidase i |
摘要 |
A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity. |
申请公布号 |
BRPI0919764(A2) |
申请公布日期 |
2016.05.03 |
申请号 |
BR2009PI19764 |
申请日期 |
2009.10.21 |
申请人 |
JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH & DEVELOPMENT, L.L.C. |
发明人 |
MATTHEW OLSON;MATTHEW TODD |
分类号 |
C07K7/06;C07K7/08;C07K14/81;C12Q1/37 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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