OxyVu-1 hyperspectral tissue oxygenation (HTO) measurement system

摘要

The invention is directed to a hyperspectral/multispectral system referred to as the OxyVu-1 system. The hyperspectral imaging technology performs spectral analysis at each point in a two-dimensional scanned a producing an image displaying information derived from the analysis. For the OxyVu-1 system, the spectral analytical methods determined in superficial tissues approximate values of oxygen saturation (HT-Sat), oxyhemoglobin levels (HT-oxy), and deoxyhemoglobin levels (HT-deoxy). The OxyVu-1 system displays the tissue oxygenation in a two-dimensional, color-coded image. The system contains a system console, a cart, system electronics, CPU, monitor, keyboard, pointing device and printer. The hyperspectral instrument head with support arm contains broadband illuminator, camera and spectral filter for collecting hyperspectral imaging cube. The single use OxyVu Check Pads and Targets are used to perform an instrument check prior to patient measurements. The OxyVu Target is placed within the intended field of view and is used as a fiduciary mark for image registration and for focusing.

主权项

1. A hyperspectral/multispectral medical imaging system, comprising:
an illumination system that is configured to illuminate a subject; an optical acquisition system that is configured to acquire reflected light from a subject; a central processing unit (CPU); memory; and a plurality of program modules stored in the memory and configured to be executed by the CPU, the plurality of program modules including:
a calibration module, anda data acquisition module, wherein the calibration module includes instructions for:
(A) calibrating illumination power and uniformity of the illumination system by a procedure comprising:
(i) acquiring a hyperspectral/multispectral image of a calibration pad comprising a surface having a predetermined reflectance, the hyperspectral/multispectral image comprising a plurality of sub-images of the calibration pad illuminated by the illumination system, each respective sub-image in the plurality of sub-images acquired at a corresponding spectral band;(ii) subtracting a dark radiation image from the hyperspectral/multispectral image, the dark radiation image acquired previously when the optical acquisition system was blocked from light;(iii) determining, for each respective sub-image of the hyperspectral/multispectral image, the measured value of light reflectance across the calibration pad at the corresponding spectral band of the respective sub-image;(iv) determining a maximum deviation, for each respective sub-image of the hyperspectral/multispectral image, between the measured value of light reflectance across the calibration pad at the corresponding spectral band of the respective sub-image and an ideal value of light reflectance across the calibration pad at the corresponding spectral band of the respective sub-image;(v) comparing the maximum deviation for each respective sub-image of the hyperspectral/multispectral image to a first threshold value; and(vi) determining a success of the calibrating (A) wherein
the calibrating (A) is deemed to have failed when the maximum deviation for a sub-image of the first hyperspectral/multispectral image of exceeds the first threshold value, andthe calibrating (A) is deemed to have passed when the maximum deviation for a sub-image of the hyperspectral/multispectral image does not exceed the first threshold value;(B) calibrating wavelength accuracy of the optical acquisition system; and(C) calibrating image focus of the optical acquisition system.