Antipsychotic treatment based on SNP genotype

摘要

The present invention relates to the prediction of antipsychotic treatment efficacy based on a patient's genotype at one or more single nucleotide polymorphism (SNP) loci and to the treatment of a patient based on such prediction.

主权项

1. A method of treating a human individual with at least one psychotic symptom comprising:
a) determining the individual's genotype at the single nucleotide polymorphism (SNP) locus rs4528226; and b) administering to the individual a first effective amount of between about 2 mg/day and about 24 mg/day of iloperidone, a pharmaceutically-acceptable salt thereof, a metabolite thereof, or a pharmaceutically-acceptable salt of a metabolite thereof in the case that the individual's genotype at rs4528226 is GT; or administering to the individual a second effective amount of iloperidone, a pharmaceutically-acceptable salt thereof, a metabolite thereof, or a pharmaceutically-acceptable salt of a metabolite thereof in the case that the individual's genotype at rs4528226 is not GT, wherein the second effective amount is between about 24 mg/day and about 50 mg/day and greater than the amount administered to an individual that has a GT genotype at the rs4528226 locus.