Markers for susceptibility to an inhibitor of an Src-family kinase

摘要

The present invention relates to a method for predicting the responsiveness of a mammalian tumor cell or cancer cell to an inhibitor of a kinase of the Src family, such as dasatinib, bosutinib, saracatinib or ponatinib. The present invention also provides for a method for predicting the responsiveness of an individual to an inhibitor of a kinase of the Src family, whereby the individual is suspected to suffer from cancer. These methods involve the evaluation of the status of integrin β4, wherein said status is indicative for the responsiveness to the inhibitor. Furthermore, a kit useful for carrying out the methods described herein as well as an oligo—or polynucleotide and/or antibodies capable of detecting the expression level of integrin β4 for predicting the responsiveness to the inhibitor are provided.

主权项

1. A method for the treatment of cancer comprising:
administering an effective amount of an inhibitor of a kinase of the Src family to a subject in need of such a treatment, wherein the subject in need of such treatment is identified by evaluating phosphorylation of integrin β4 (ITGB4) at one or more phosphorylation sites selected from S1518, S1457, T1455 and S1069 of ITGB4 in a sample of a subject suspected to suffer from cancer, suffering from cancer or being prone to suffer from cancer, and wherein an increase in phosphorylation of one or more phosphorylation sites compared to a control indicates responsiveness of the subject to the inhibitor of a kinase of the Src family.