Peptide derivatives and use thereof as carriers for molecules in the form of conjugates

摘要

The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorize molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).

主权项

1. A cyclic peptide or pseudo-peptide which binds human low-density lipoprotein receptor (hLDLR), is 5-8 amino acids in length and comprises the following sequence:
X-M-P-R-Y wherein:
M designates methionine;P designates proline or an analogue thereof;R designates arginine;X designates cysteine or an analogue of a cysteine; andY is a peptide of 1 to 4 amino acids comprising a cysteine or an analogue of cysteine.