| 发明名称 | Diazole lactams | ||
| 摘要 | Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists. | ||
| 申请公布号 | US9328116(B2) | 申请公布日期 | 2016.05.03 |
| 申请号 | US201314099541 | 申请日期 | 2013.12.06 |
| 申请人 | ChemoCentryx, Inc. | 发明人 | Chen Xi;Fan Pingchen;Li Yandong;Powers Jay P.;Malathong Viengkham;Punna Sreenivas;Tanaka Hiroko;Zhang Penglie;Dragoli Dean |
| 分类号 | A61K31/55;A61K31/4196;A61K31/4155;C07D487/04;A61K45/06;C07D401/14;C07D403/14;C07D405/14;C07D471/04 | 主分类号 | A61K31/55 |
| 代理机构 | Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. | 代理人 | Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. |
| 主权项 | 1. A compound selected from the group consisting of: or a pharmaceutically acceptable salt, hydrate, solvate, rotamer or N-oxide thereof. | ||
| 地址 | Mountain View CA US | ||