Degradation-stabilised, biocompatible collagen matrices

摘要

The present invention relates to degradation-stabilized, biocompatible collagen matrices which are distinguished in particular by the fact that they contain soluble collagen and peptide constituents, to processes for the preparation of such collagen matrices, which processes include in particular chemical crosslinking with an epoxy-functional crosslinking agent, and to the use of the collagen matrices according to the invention as a cosmetic or pharmaceutical agent, in particular for topical use, and as a wound treatment agent, as an implant or as a haemostatic agent in humans or animals, and as a scaffold for cell population in the biotechnology, basic research and tissue engineering field.

主权项

1. A crosslinked collagen matrix obtained by a process comprising:
a) preparing an aqueous collagen suspension, b) adjusting the pH value of the collagen suspension from step a) to pH <4, c) adding an epoxy-functional crosslinking agent in an amount of not more than 50 wt. % based on the dry mass of the collagen suspension from step a), d) freezing the collagen mixture obtainable from step d), e) freeze-drying of the frozen mixture from step e) at a freeze-drying temperature <100° C., f) adjusting the freeze-dried crosslinked collagen material so obtained to a moisture content from 3 to 25 wt. %, based on the end product, and g) at least one of sterilizing and processing the formed materials.