发明名称 |
High-efficiency nanoparticle-type double-helical oligo-RNA structure and method for preparing same |
摘要 |
Provided are a double-stranded oligo RNA structure and a method of preparing the same, and more specifically, a double-stranded oligo RNA structure in which a polymer compound is covalently bound to a double-stranded oligo RNA in order to improve stability in vivo and a cell delivery efficiency of the double-stranded oligo RNA, and a method of preparing the same.;The double-stranded oligo RNA structure having the optimized structure according to the present invention may not inhibit functions of the double-stranded oligo RNA, but effectively improve stability and cell membrane permeability of the double-stranded oligo RNA, such that the double-stranded oligo RNA may be delivered into the cell even at a low concentration dosage thereof to be significantly used as a tool for treatment of cancer, infectious diseases, and the like, as well as a new delivery system of the double-stranded oligo RNA. |
申请公布号 |
US9326941(B2) |
申请公布日期 |
2016.05.03 |
申请号 |
US201314370035 |
申请日期 |
2013.01.04 |
申请人 |
BIONEER CORPORATION |
发明人 |
Chae Jeiwook;Han Boram;Kim Han-na;Park Han Oh |
分类号 |
A61K48/00;C07H21/02;C07H21/04;A61K9/14;C12N15/11;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
Hultquist, PLLC |
代理人 |
Hultquist, PLLC ;Hultquist Steven J. |
主权项 |
1. A double-stranded oligo RNA structure to which a chemical material having a structure represented by the following formula 1 is bound:wherein one of A and B is a hydrophilic material, the other one is a hydrophobic material, X and Y are each a simple covalent bond or a linker-mediated covalent bond independently of each other, S is a sense strand of the double-stranded oligo RNA, and AS is an antisense strand of the double-stranded oligo RNA. |
地址 |
Daejeon KR |