Method for automatic, unsupervised classification of high-frequency oscillations in physiological recordings

摘要

Oscillatory signals may be used to determine a region of a patient's body that is associated with a medical condition. As described herein, oscillatory signals may be detected using a high sensitivity, low specificity detector. The oscillatory signals may be representative of discrete events in a patient's body. The detected signals may be tested in the context of surrounding background activity to identify anomalous discrete physiologic events that are sufficiently different from the surrounding background activity. The anomalous discrete physiologic events having correlative morphological, time, or location characteristics may be automatically clustered and clusters of anomalous physiologic events may be determined that are indicative of at least one region of the patient's body that is associated with a medical condition.

主权项

1. A method for automatically detecting, classifying, and processing oscillatory signals for use as a biomarker for a physiologic physiological event in a patient, the method comprising:
detecting and classifying oscillatory signals representative of discrete physiologic events in a patient's body using a high sensitivity, low specificity detector; processing, using a processor, the detected signals by:
testing the detected signals in the context of surrounding background activity to identify anomalous discrete physiologic events that are sufficiently different from the surrounding background activity; andautomatically clustering said anomalous discrete physiologic events into clusters of anomalous physiologic events having correlative morphological, time, or location characteristics; determining at least one cluster of anomalous physiologic events as a biomarker indicative of at least one region of the patient's body that is associated with a medical condition; and providing treatment, using a treatment device responsive to said biomarker, of said medical condition to the at least one region of the patient's body identified by said biomarker.