Method for producing an organ replica, in particular a functional model

摘要

A method for designing or replicating a human or animal organ in the form of a functional model includes providing previously recorded structural-geometric data of the organ or organ part to be replicated, selecting reconstruction materials for the organ or organ part, allocating the structural-geometric data to the individually selected reconstruction materials, and carrying out a layered assembly by the model by successively applying site-selective assembly methods for at least one part of the reconstruction materials on the basis of an associated data set.

主权项

1. A method for producing a model of a human or animal organ or of a part thereof or of some other segment of a human or animal body, comprising the steps of:
a) providing precaptured structural geometric data of the organ, organ part or segment to be replicated, which structural geometric data form a data set composed of information relating to a material type or a material class assigned to a three-dimensional positioning in space, wherein the structural geometric data are obtained from stained section images, or are determined noninvasively on a living body; b) selecting reconstruction materials for the organ, organ part or segment to be replicated, comprising at least one material for the reconstruction of an extracellular matrix and at least one type of organ-specific cells; c) assigning the structural geometric data to individual selected reconstruction materials of said reconstruction materials selected in said selecting step on the basis of measured values from section images; d) assembling the model layer-by-layer through successive application of site-selective assembly methods for at least some of the reconstruction materials which include both the at least one material for the reconstruction of the extracellular matrix and the at least one type of organ-specific cells based on an associated data set, and wherein a site-selective assembly method used for a layer-by-layer replication of cellular layers and regions is a Laser Induced Forward Transfer (LIFT) of the cells.