Branched polymeric quaternary ammonium compounds and their uses

摘要

Biocidal branched quaternary ammonium polymers are made by condensing a difunctional halide with a trifunctional tertiary amine and optionally with a difunctional amine. The branched quaternary ammonium polymers have 2-dimensional conformation that provides better coverage over the surfaces of microorganisms and enhances efficacy as biocides as compared to most commercially available linear (one-dimensional) quaternary ammonium polymers. The bulkier 2-dimensional conformation of this invention limits the uptake, accumulation and release of these branched polymers to and from contact lenses. Therefore, these branched quaternary ammonium polymers can reduce the cytotoxicity, enhance compatibility and suitable for ophthalmic use. The highly branched polymers can be prepared with minimum or no difunctional tertiary amines. The lightly branched polymers can be prepared with of a minimum ratio of trifunctional tertiary amines/difunctional tertiary amines.

主权项

1. A biocide solution comprising a polymer having at least one branched quaternary ammonium unit of the following formula 1: wherein R1, R2, R3, R4, R5, and R6 independently represent alkyl groups having 1-3 carbon atoms optionally substituted with OH, OMe, OEt, OPr, aryl groups or quaternary ammoniums groups; linkers represent independently the same or different linkage groups with 2, 3, or more points of connections for quaternary ammonium groups and at least one of the linkers has 3 or more connections or at least 0.01% of the linkers has 3 or more connections; and l, m, and n represent an integer varying from 1 to 5000.