Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same

摘要

Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.

主权项

1. A method of reducing occurrence of a bacterial infection in a human in need of treprostinil, comprising diluting a starting solution comprising the treprostinil with a buffer comprising glycine and having a pH of greater than 10 to provide a final solution comprising the treprostinil with a pH of greater than 10 and administering the final solution to the human in need thereof.