| 发明名称 |
Multifunctional antibodies binding to EGFR and MET |
| 摘要 |
Provided are multifunctional antibodies, and/or antigen-binding fragments, that bind to, and inhibit the activity of, both human epidermal growth factor receptor (EGFR) and MET, and that are effective in treating cancers and other diseases, disorders, or conditions where pathogenesis is mediated by EGFR and MET. |
| 申请公布号 |
US9328173(B2) |
申请公布日期 |
2016.05.03 |
| 申请号 |
US201414573373 |
申请日期 |
2014.12.17 |
| 申请人 |
Eli Lilly and Company |
发明人 |
Aldaz Hector;Allan Barrett;Liu Ling;Lu Jirong;Tang Ying;Tschang Sheng-Hung Rainbow;Yachi Pia Pauliina |
| 分类号 |
C07K16/40;C07K16/28;C07K16/30;A61K39/00 |
主分类号 |
C07K16/40 |
| 代理机构 |
|
代理人 |
Sharp Robert L. |
| 主权项 |
1. A multifunctional antibody that binds MET and EGFR comprising:
(a) two first polypeptides wherein both first polypeptides comprise the amino acid sequence of SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 29, SEQ ID NO: 31, or SEQ ID NO: 52; and (b) two second polypeptides wherein both second polypeptides comprise the amino acid sequence of SEQ ID NO: 33. |
| 地址 |
Indianapolis IN US |
